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Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives

โœ Scribed by Nadine Azas; Pascal Rathelot; Serge Djekou; Florence Delmas; A Gellis; Carole Di Giorgio; Patrice Vanelle; Pierre Timon-David


Book ID
113619627
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
396 KB
Volume
58
Category
Article
ISSN
0014-827X

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The synthesis and SAR studies of thieno [2,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists to treat reproductive diseases are discussed. It was found that the 2-(2-pyridyl)ethyl group on the 5-aminomethyl functionality of the core structure was a key feature for good receptor binding ac