Antioxidants inhibit TNFα-induced motility and invasion of human osteosarcoma cells: Possible involvement of NFκB activation
✍ Scribed by Katsumi Harimaya; Kazuhiro Tanaka; Yoshihiro Matsumoto; Hideshi Sato; Shuichi Matsuda; Yukihide Iwamoto
- Book ID
- 110241264
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 155 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0262-0898
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## Abstract Tumor necrosis factor‐alpha (TNFα) induces cancer development and metastasis, which is prominently achieved by nuclear factor‐kappa B (NF‐κB) activation. TNFα‐induced NF‐κB activation enhances cellular mechanisms including proliferation, migration, and invasion. KiSS1, a key regulator o
## Abstract Osteosarcoma is characterized by a high malignant and metastatic potential. The chemokine stromal‐derived factor‐1α (SDF‐1α) and its receptor, CXCR4, play a crucial role in adhesion and migration of human cancer cells. Integrins are the major adhesive molecules in mammalian cells, and h