Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse

TNF α-induced ras activation due to etha

TNF α-induced ras activation due to ethanol promotes hepatocyte proliferation independently of liver injury in the mouse

✍ Fuyumi Isayama; Matthias Froh; Ming Yin; Lars O. Conzelmann; Richard J. Milton; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 776 KB

Tumor necrosis factor ␣ (TNF␣) has been shown to be both proapoptotic and mitogenic for hepatocytes and necessary for alcohol-induced liver injury. Ras, a known proto-oncogene, is very important in the regulation of cellular responses to TNF␣. Therefore, the purpose of this study was to investigate