Antioxidant activity of Osbeckia aspera

✍ Scribed by M. Ira Thabrew; Robin D. Hughes; Ian G. McFarlane

• Book ID: 101289407
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 83 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199806)12:4<288::aid-ptr228>3.0.co;2-6

✦ Synopsis

Plants of the Osbeckia family have been shown to possess hepatoprotective properties, which could be due to the presence of antioxidant compounds. The plant extract was shown to inhibit significantly in a dose-dependent manner, the activities of the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical (EC 50 of 27.5 mg/mL), xanthine oxidase (EC 50 of 1.16 mg/mL) and demonstrate a scavenging effect on hydroxyl radical mediated damage to deoxyribose (EC 50 of 140 mg/mL). The plant extract possessed some prooxidant activity from the effect on bleomycin-induced DNA damage, but this was less than that shown by comparable concentrations of ()-catechin or silymarin.