Antioxidant Action of Tetrandrine: An Alkaloid from the Roots ofRadix stephania tetrandra, S Moore
✍ Scribed by Cao, Zhao-feng; Zhu, Xin-qiu
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 275 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-5142
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✦ Synopsis
The antioxidant action of the alkaloid tetrandrine(TD), was investigated using systems generating biologically relevant reactive oxygen species. TD appeared to scavenge produced in a mixture of EDTA-Fe3/ascorbate and OHã nd suppressed the peroxidation of phospholipid liposomes in the pres-H 2 O 2 ence of iron(III) and ascorbate. TD was a good scavenger toward trichloromethyl peroxyl with a rate constant of 6É5 ^0É3 ] 107 M~1 s~1 generated by pulse radiolysis. TD did not promote DNA damage in the bleomycin-Fe3s ystem and a concentration up to 500 kM produced a weak inhibition of DNA damage by bleomycin-Fe3in the presence of ascorbic acid. The present data suggest that TD possess antioxidant properties.