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Antioestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Benth. in rats

✍ Scribed by A. M. Luna Costa; J. C. R. Silva; A. R. Campos; V. S. N. Rao; M. A. M. Maciel; A. C. Pinto

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 56 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199912)13:8<689::aid-ptr532>3.0.co;2-l

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✦ Synopsis

This study examined trans-dehydrocrotonin (t-DCTN), a nor-clerodane diterpene isolated from the Brazilian medicinal plant Croton cajucara Benth., for a possible antioestrogenic activity using immature rats as a model system for bioassay of oestrogen, and for an antiimplantation effect in regularly cycling rats of proven fertility. In the antioestrogen test, t-DCTN (25 and 50 mg/kg) effectively prevented oestrogeninduced increases of uterine wet weights. In addition, the vaginal openings provoked by oestrogen were completely prevented by t-DCTN. However, blastocyst-implantation was only insignificantly affected in t-DCTN pretreated animals. These results suggest that t-DCTN may be an antioestrogen and warrants further studies with regard to its mechanism of action.

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Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara

✍ Aniele R. Agner; Maria A.M. Maciel; Angelo C. Pinto; Sônia G.S.R. Pamplona; Ilce 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 56 KB 👁 1 views

The genotoxic action of three doses of trans-dehydrocrotonin (t-DCTN), an active ingredient obtained from the bark extracts of an Amazon native plant, Croton cajucara, were examined in Swiss mouse bone marrow cells in vivo, submitted to acute intraperitoneal treatment, by micronucleus (MN) and chrom