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Antinuclear antibodies: A marker associated with steroid dependence in patients with ulcerative colitis

✍ Scribed by J. Barahona-Garrido; J. Camacho-Escobedo; C.I. García-Martínez; H. Tocay; J. Cabiedes; J.K. Yamamoto-Furusho

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
102 KB
Volume
15
Category
Article
ISSN
1078-0998

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✦ Synopsis

Background:

The autoimmune phenomena and the autoantibody profile have acquired great importance in ulcerative colitis (UC). Few studies have explored antinuclear antibodies (ANAs) prevalence, but not its association with steroid dependence. We hypothesized that ANAs could be a factor associated to steroid dependence.

Methods: Ninety-seven consecutive patients with UC were included. ANA titers and staining patterns were determined by indirect immunofluorescence. Gender, age, follow-up time, C-reactive protein (CRP), disease extent, Mayo Score Activity Index, extraintestinal manifestations, and steroid dependence were analyzed in univariate and multivariate models.

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