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Antinociceptive effects in rodents of the dipeptide Lys-Trp (Nps) and related compounds

✍ Scribed by Garcia-Lopez, M.T.; Herranz, R.; Gonzalez-Muñiz, R.; Naranjo, J.R.; De Ceballos, M.L.; Del Rio, J.

Book ID
123218846
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
457 KB
Volume
7
Category
Article
ISSN
0196-9781

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Analgesic Dipeptides VI.: Synthesis and
Analgesic Dipeptides VI.: Synthesis and Structure-Activity Relationships of N-Terminal Modified Analogues of the Analgesic Compounds H-Xaa-Trp (Nps)-OMe (Xaa=Lys, Orn, Arg)
✍ M. Teresa García-López; Rosario González-Muñiz; Juan R. Harto; M. Teresa Moliner 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 613 KB

In order to determine the influence of the N-terminal amino group of the dipeptide derivatives H-Xaa-Trp@ps)-OMe[Xaa=Lys (2a). Om (2b). Arg ( 2 4 on their antinociceptive effects, the syntheses of their cmponding deaminated. acetylated and dimethylated analogues have been achieved. Deamino and dime