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Antinociceptive activity of metapramine in mice. Relationship with its pharmacokinetic properties

โœ Scribed by J. Fialip; H. Marty; O. Aumaitre; A.M. Bougerolle; G. Dordain; J.A. Berger; A. Eschalier


Book ID
118345458
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
481 KB
Volume
50
Category
Article
ISSN
0024-3205

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โœ E. Dailly; M. Hascoรซt; M. C. Colombel; P. Jolliet; M. Bourin ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 88 KB

The relationship between the cerebral pharmacokinetics of diazepam and its active metabolites (desmethyldiazepam, oxazepam) and the anxiolytic effect evaluated by the four-plates test and the light/dark test were investigated after a single intra-peritoneal injection of diazepam (1 mg/kg or 1.5 mg/k