Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice

✍ Scribed by Denis Brochet; Juan-Antonio Micó; Patrick Martin; Pierre Simon

• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 204 KB
• Volume: 88
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00178520

✦ Synopsis

Clenbuterol, isoproterenol and salbutamol increased the latency in the licking response of mice on the hot plate at 56.5 ° C. This effect was dose-related and obtained after IP administration. Clenbuterol was active at lower doses than isoproterenol and salbutamol, a result which is consistent with its better penetration in the central nervous system. Moreover, the effect of clenbuterol was stereospecific, the (-)-isomer being the active form. Our results suggest the implication of central beta-adrenoceptors in the modulation of the response to a painful stimulation.