Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. characterization and clinical correlations
β Scribed by A. H. L. Mulder; G. Horst; M. A. Van Leeuwen; P. C. Limburg; C. G. M. Kallenberg
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 757 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0004-3591
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Objective. To investigate the pathogenetic role of antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis (WG). Methods. BALBlc mice were immunized with human IgG ANCA from a patient with WG. Control mice were immunized with normal human IgG. Levels of mouse ANCA and other autoant
## Abstract ## Objective Antineutrophil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are detectable in most patients with cocaineβinduced midline destructive lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown