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Antineoplastic activity of ASTA Z 7557 (INN mafosfamide) in transplanted and autochthonous experimental rodent tumors

✍ Scribed by W. Jens Zeller; Martin R. Berger; Ronald Matys; Jochen Schuhmacher

Publisher: Springer US
Year: 1984
Tongue: English
Weight: 675 KB
Volume: 2
Category: Article
ISSN: 0167-6997
DOI: 10.1007/bf00232348

No coin nor oath required. For personal study only.

✦ Synopsis

The antineoplastic activities of ASTA Z 7557 and cyclophosphamide (CPA) were compared in advanced transplanted AKR lymphoma by determining the optimal dose using single dose and twofold applications. Autochthonous DMBA-induced leukemias and MNU-induced mammary carcinomas were treated with fractionated doses over 3 and 5 weeks, respectively. In the respective optimal dosages ASTA Z 7557 exhibited an antitumor effect comparable to that of CPA in all three models. The results obtained by treatment of the autochthonous models indicate that Z 7557 seems to have advantages over CPA in the treatment of malignancies with impaired bone marrow function as for instance acute leukemias and in fractionated dose schedules.

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