Antimony trichloride catalyzed three-component reaction of urea, aldehydes and cyclic enol ethers: a novel route to 4-arylhexahydrofuro[2,3-d]pyrimidin-2(3H)-ones

✍ Scribed by R.N. Bhattacharya; Pradip Kundu; Gourhari Maiti

• Book ID: 104098470
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 262 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.10.064

✦ Synopsis

4-Arylhexahydrofuro[2,3-d]pyrimidin-2(3H)-ones 4-Arylhexahydro-1H-pyrano[2,3d]pyrimidin-2(8aH)-ones a b s t r a c t Antimony trichloride efficiently catalyses diastereoselective three-component reaction of urea, aromatic aldehydes and 2,3-dihydrofuran or 3,4-dihydro-2H-pyran leading to 4-arylhexahydrofuro[2,3-d]pyrimidin-2(3H)-ones and 4-arylhexahydro-1H-pyrano[2,3-d]pyrimidin-2(8aH)-ones, respectively in good yield.