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Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action

✍ Scribed by Hiroyuki Haraguchi; Shintaro Kataoka; Shiho Okamoto; Muhammad Hanafi; Kozo Shibata

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 94 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199903)13:2<151::aid-ptr391>3.0.co;2-c

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✦ Synopsis

Antimicrobial triterpenes were isolated from the fruits of Ilex integra. Their structures were elucidated by spectral data and identified as rotundic acid (1), ulsolic acid (2) and peduncloside (3). Triterpene 1 showed significantly broad antimicrobial activity against bacteria, yeast and filamentous fungi. The antifungal activity of 1 was reversed by fatty acids. Cellular constituents leaked from Candida albicans cells incubated with triterpene 1. These results suggest that the antimicrobial activity of triterpenes in I. integra is due to a change of membrane permeability arising from membrane lipid alteration. Copyright

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