β Scribed by JΓΌrgen Harder, Jens-M. SchrΓΆder (eds.)
No coin nor oath required. For personal study only.
This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMPβs specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits β a question that is discussed in the final chapter.
Front Matter....Pages i-vi
Antimicrobial Peptides in Cutaneous Wound Healing....Pages 1-15
Antimicrobial Peptides as Endogenous Antibacterials and Antivirals at the Ocular Surface....Pages 17-32
Function of Antimicrobial Peptides in Lung Innate Immunity....Pages 33-52
Antimicrobial Peptides: Maintaining Sterility of the Urinary Tract....Pages 53-65
Antimicrobial Peptides in the Gut....Pages 67-88
Metal Sequestration: An Important Contribution of Antimicrobial Peptides to Nutritional Immunity....Pages 89-100
Regulation of Antimicrobial Peptide Gene Expression by Vitamin D....Pages 101-113
Dichotomous Roles of Cationic Polypeptides Targeting HIV....Pages 115-127
Antimicrobial Peptides in Host Defense: Functions Beyond Antimicrobial Activity....Pages 129-146
Antimicrobial Peptides: Do They Have a Future as Therapeutics?....Pages 147-154
Back Matter....Pages 155-158
Immunology; Microbiology
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