Antimicrobial fragments of the pro-region of cathelicidins and other immune peptides
✍ Scribed by Rachel C. Anderson; Maren Rehders; Pak-Lam Yu
- Publisher
- Springer Netherlands
- Year
- 2008
- Tongue
- English
- Weight
- 170 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0141-5492
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## Abstract Recently, we designed a novel cell‐selective antimicrobial peptide (TPk) with intracellular mode of action from Pro → Nlys (Lys peptoid residue) substitution in a noncell‐selective cathelicidin‐derived Trp/Pro‐rich antimicrobial peptide, tritrpticin‐amide (TP; VRRFPWWWPFLRR‐NH~2~) (__Bi
## Abstract Cathelicidins comprise a major family of host‐defense antimicrobial peptides in vertebrates. The C‐terminal part of the cathelicidins is bestowed with antimicrobial and lipopolysaccharide (LPS) neutralizing activities. In this work, we repot high resolution solution structures of two no