Antimicrobial diterpenes from Polyalthia longifolia var. pendulla (Annonaceae)

✍ Scribed by M. A. Rashid; M. A. Hossain; C. M. Hasan; M. S. Reza

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 282 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199602)10:1<79::aid-ptr774>3.0.co;2-d

✦ Synopsis

The antimicrobial activities of the petroleum ether extract of the stem bark of Polyawria Zongifoliu var. pendub as well as the diterpenes isolated from it were studied. Among the diterpenoids, 16-oxoclerada-3,13E-dien-15-oic acid (1) exhibited the highest activities against most of the bacteria and the kanamycin resistant fungal strains, Aspengillus fumigatus, Saccharmmyces caulbequence and S . cerevaceae, Candida albicans and Hensila calgornica compared with those of kdavenic acid (2) and 16/?-hydroxycleroda-3,13-dien-15,16-0lide (3). The minimum inhibitory concentrations for all of these compounds were determined and were found to be 8-64 &mL.