Antimicrobial Depsides Produced by Cladosporium uredinicola, an Endophytic Fungus Isolated from Psidium guajava Fruits
✍ Scribed by Lívia Soman de Medeiros; Michael Murgu; Antônia Q. L. de Souza; Edson Rodrigues-Fo.
- Book ID
- 102257548
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- German
- Weight
- 180 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Four depsides, all of them new as natural products, were isolated from Cladosporium uredinicola solid-media culture and identified as 3-hydroxy-2,5-dimethylphenyl 2,4-dihydroxy-3,6-dimethylbenzoate (1), 3-hydroxy-2,4,5-trimethylphenyl 2,4-dihydroxy-3,6-dimethylbenzoate (2), 3-hydroxy-2,5-dimethylphenyl 3-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-6-hydroxy-2,4-dimethylbenzoate (3), and 3-hydroxy-2,4,5-trimethylphenyl 3-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-6-hydroxy-2,4-dimethylbenzoate (4). The endophytic fungus was isolated from Psidium guajava fruits and cultivated over sterilized rice. The compounds 1 -4 were purified by classical chromatographic procedures, and the chemical structures were identified by spectroscopic studies, mainly 1D-and 2D-NMR and LC/ESI-MS/MS. Three of the isolated depsides exhibited moderate bacteriostatic and/or bactericide effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtillis.