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Antimicrobial activity of statistical polymethacrylic sulfopropylbetaines against gram-positive and gram-negative bacteria

✍ Scribed by Marty Ward; Melissa Sanchez; Mohamed O. Elasri; Andrew B. Lowe

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
85 KB
Volume
101
Category
Article
ISSN
0021-8995

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✦ Synopsis

Abstract

A series of statistical copolymers derived from 2‐(dimethylamino)ethyl methacrylate with four different hydrophobic comonomers (ethyl, butyl, cyclohexyl, and octyl methacrylates) have been prepared via conventional free radical copolymerization under bulk conditions. The copolymers have been subsequently modified, with 1,3‐propanesultone to yield the corresponding polysulfoproylbetaine derivatives. Those copolymers exhibiting the requisite aqueous solubility have been screened with respect to their antimicrobial activity against two common and notorious pathogens, namely Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). We show that certain copolymers do indeed exhibit antimicrobial activity. The extent of activity is related to the molecular characteristics of the materials such as the molar composition and structure of the hydrophobic comonomer. Β© 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 1036–1041, 2006

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