𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Antimicrobial activity of amino acid, imidazole, and sulfonamide derivatives of pyrazolo[3,4-d]pyrimidine

✍ Scribed by M. M. Ghorab; Zeinab H. Ismail; Soad M. Abdel-Gawad; Anhar Abdel Aziem

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
100 KB
Volume
15
Category
Article
ISSN
1042-7163

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Derivatives of pyrazolo[3,4‐d]pyrimidine with amino acid 3a–d, imidazole 4a–d, carbonyl 6–9, pyrazole 10, pyrazolone 11, and sulfonamide 12–17 moieties were synthesized. Structure of the new compounds were established by their elemental analyses and spectral data. Some of the synthesized compounds were tested in vitro for their antimicrobial activity. Compounds 4b, 12, and 16 were almost as potent as the standard antibiotic Chloramphenicol as positive control. Also, compounds 3b, 3c, 12, and 16 were nearly as active as Terbinafine as positive control. Β© 2003 Wiley Periodicals, Inc. 15:57–62, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/.hc10212

πŸ“œ SIMILAR VOLUMES

Design, synthesis, and antimicrobial act
Design, synthesis, and antimicrobial activity of some new pyrazolo[3,4-d]pyrimidines
✍ Soad M. Abdel-Gawad; M. M. Ghorab; A. M. Sh. El-Sharief; F. A. El-Telbany; M. Ab πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 111 KB

## Abstract 2‐Benzyl‐ and 2‐aryloxymethyl‐3‐amino‐1‐phenyl‐pyrazolo[3,4‐__d__]pyrimidine‐4‐ones **__5a–f__** have been synthesized by reacting the corresponding arylacetylamino derivatives **__3a–f__** with hydrazine hydrate. Thionation of compounds **__5d–f__** by action of P~2~S~5~ in pyridine yi