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Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

✍ Scribed by Hiroaki Miyaoka; Masako Shimomura; Haruko Kimura; Yasuji Yamada; Hye-Sook Kim; Wataya Yusuke

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 407 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00818-7

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✦ Synopsis

Three new kalihinane diterpenoids A9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

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