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Antimalarial Activity of Alkaloids from Pogonopus tubulosus

✍ Scribed by Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; Enma Ruiz; Bernard Richard; Louisette Le Men-Olivier

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
312 KB
Volume
10
Category
Article
ISSN
0951-418X

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✦ Synopsis

The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium fakiparum and by in vivo tests on I! berghei and t? vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC, of 0.006 pg/ mL against the sensitive strain of t? fakiparum and an IC,, of 0.011 pg/mL against the resistant strain oft? fakiparum. This compound had good in vivo antimalarial activity with an ED,, of 0.05 mg/kg/day on t? vinckei petten' strain and an ED, of 0.45 mg/kg/day on f? berghei.

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