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Antimalarial Activity and Toxicity of a Metabolic Derivative of Quinine

✍ Scribed by KELSEY, F. E.; OLDHAM, F. K.; CANTRELL, W.; GEILING, E. M. K.


Book ID
109548013
Publisher
Nature Publishing Group
Year
1946
Tongue
English
Weight
129 KB
Volume
157
Category
Article
ISSN
0028-0836

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The organophosphate insecticide imidan includes a phthalimide group. Because of the structural relationship to the teratogenic compound thalidomide we have investigated its placental transfer and metabolic fate in rats. Its passage to embryonic tissues could be confirmed. After intraamniotic injecti