Antimalarial activity and conformation of erythro- and threo-.alpha.-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol

14C-labeled antimalarials. I. Synthesis

14C-labeled antimalarials. I. Synthesis of dl-erythro- and threo-α(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol-α-14C

✍ William H. Yanko; George F. Deebel 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 291 KB

## Abstract Erythro‐ and threo‐ isomers of α‐(2‐piperidyl)‐2,8‐bis‐(triflucoromethyl)‐4‐quinolinemethanol‐α‐^14^C hydrochloride and methanesulfonate were prepared from labeled carbon dioxide for metabolic and pharmacological studies. Intermediates were 2,8‐bis(trifluoromethyl) cinchoninic‐carboxy‐^