✦ LIBER ✦

Antileukemic action of new aromatic bisguanylhydrazone derivatives

✍ Scribed by E. Mihich

Book ID: 101323950
Publisher: John Wiley and Sons
Year: 1967
Tongue: English
Weight: 376 KB
Volume: 20
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(1967)20:5<880::aid-cncr2820200548>3.0.co;2-c

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✦ Synopsis

T h e clinical usefulness of methylglyoxal-bis(guanylhydra6one) (CH,-G) as an antileukemic agent is reduced by its substantial toxicity. Of more than 200 analogues of CH,-G tested, none showed significant antileukemic effects in mice. T w o aromatic bisguanylhydrazones with borderline activity h a d marked effects against leukemia L1210 in DBA/2 H a mice when given in combination with hydroxystilbamidine. Since the diamidine h a d only borderline activity when given alone, this represents a n unusual example of synergism in cancer chemo-

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