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Antiinflammatory effects of a corticosteroid and protease inhibitor agents on antigen-induced otitis media in chinchillas

✍ Scribed by Hamaguchi, Yukiyoshi; Juhn, Steven K.; Sakakura, Yasuo


Book ID
123162802
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
586 KB
Volume
9
Category
Article
ISSN
1532-818X

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0