Antiinflammatory activities of polymers ofo-methacryloyloxybenzoic acid

✍ Scribed by Grimová, J. ;Hrabák, F.

• Book ID: 102292756
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 238 KB
• Volume: 12
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820120407

✦ Synopsis

Abstract

Antiinflammatory activities of low‐ and high‐ molecular‐weight polymers of o‐methacryloyloxybenzoic acid were compared with the antiinflammatory activity of o‐acetoxybenzoic (acetylsalicylic) acid in tests on hind‐leg inflammations in rats induced by injection of either Freund's adjuvant or aqueous suspension of kaolin. The antiinflammatory activies of the orally administered polymers cooresponded to 40–90% of the activity of o‐acetoxybenzoic acid, and were not substantially dependent on the degree of polymerization.