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Antihypertensive 9-substituted 1-0xa-4,9-diazaspiro[5.5]undecan-3-ones

✍ Scribed by Clark, Robin D.; Caroon, Joan M.; Repke, David B.; Strosberg, Arthur M.; Bitter, Susan M.; Okada, Marlys D.; Michel, Anton D.; Whiting, Roger L.

Book ID
120455446
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
871 KB
Volume
26
Category
Article
ISSN
0022-2623

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Practical and divergent synthesis of 1-
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A divergent synthesis of 1-and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones is described, in which the key step is an efficient Michael addition of a lithium enolate to a tetrasubstituted olefin acceptor. A variety of substituents (butyl, phenyl, and propoxyl) were introduced at C-1

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v