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Antihyperglycaemic effect of saccharin in diabetic ob/ob mice

✍ Scribed by Clifford J Bailey; Caroline Day; Jacqueline M E Knapper; Susan L Turner; Peter R Flatt

Book ID
110002675
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
349 KB
Volume
120
Category
Article
ISSN
0007-1188

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Effect of metformin on hepatocyte insuli
Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice
✍ J. M. Lord; T. W. Atkins; C. J. Bailey πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 575 KB

The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.