Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor
โ Scribed by Alyson Fox; Satbir Kaur; Bifang Li; Moh Panesar; Uma Saha; Clare Davis; Ilaria Dragoni; Sian Colley; Tim Ritchie; Stuart Bevan; Gillian Burgess; Peter McIntyre
- Book ID
- 110008653
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 253 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0007-1188
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## Abstract The bradykinin B1 receptor (BKB1R) gene is expressed in selected tissues such as lung and kidney. In these tissues it is expressed at a very low level until induced by inflammatory mediators. Our aim has been to understand the mechanism of this regulatory process. A human BKB1R minigene
## Abstract We pursued a breeding strategy intended to generate diseaseโresistant mice with exclusive expression of the Hโ2^u^โrestricted myelin basic protein (MBP) 1โ11 peptideโspecific transgenic (Tg) Tโcell receptor (TCR) on the Tโcellโdeficient RAG1KO (Hโ2^b^) background. Utilizing specific scr