Antiherpetic Flavones from the Heartwood of Artocarpus gomezianus
β Scribed by Kittisak Likhitwitayawuid; Saowalak Chaiwiriya; Boonchoo Sritularak; Vimolmas Lipipun
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 72 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1612-1872
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β¦ Synopsis
Abstract
The heartwood of Artocarpus gomezianus was investigated for antiβherpetic principles. During the course of the separation, a new compound, artogomezianone (1), was isolated, along with the known compounds cycloartocarpin (2), isocyclomorusin (3), artocarpin (4), norcycloartocarpin (5), norartocarpetin (6), and oxyresveratrol (7). Evaluation of these isolates for inhibitory effects against herpes simplex virus (HSV) typesβ 1 and 2 was carried out using the inactivation method. Compounds 2, 3, 6 and 7 showed moderate activities against both types of HSV, while 1, 4 and 5 were basically inactive (Tableβ 2).
π SIMILAR VOLUMES
MORIN (3, 5, 7, 2', .!+I-pentahydroxyflavone) and the colourless cyanomaclurin, to which Appel and Robinson1 assigned the structure of a cyclic hemiketal of 5, 7, 2', ,!+I-tetrahydroxy-3-ketoflavan, were isolated by Perkin and Cope 2,3 from the heartwood of Artocarous inteqrifolia. We have recently