Antiherpetic Activity of S1, an Algal Derived Sulphated Galactan
✍ Scribed by Carlos A. Pujol; Maria I. Errea; Maria C. Matulewicz; Elsa B. Damonte
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 423 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The sulphated galactan S1 isolated from the red seaweed Pterocladia cupillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 pg/mL that were in excess of the IC,, values (range from 3.2 to 12.0 pg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell.