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Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats

โœ Scribed by M. Karan; K. Vasisht; S. S. Handa

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
589 KB
Volume
13
Category
Article
ISSN
0951-418X

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โœฆ Synopsis

The methanol extract of Swertia chirata was evaluated for antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice.

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