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Antigenotoxic effect of 4-methylesculetin on mice cells exposed to doxorubicin

✍ Scribed by Edson Maistro; Rafael Fedato

Book ID
116925200
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
102 KB
Volume
211
Category
Article
ISSN
0378-4274

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We report the inhibitory effect of 4-methylesculetin (ME), a 4methylumbelliferone derivative, on hyaluronan (HA) synthesis by pancreatic cancer cells, and its resulting anticancer action. First, HA in cell culture was analyzed using competitive inhibition with hyaluronic acid-binding protein (HABP)