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Antigenicity of rhabdomyosarcomas induced by nickel sulfide (Ni3S2)

✍ Scribed by Lynette B. Corbeil


Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
543 KB
Volume
21
Category
Article
ISSN
0008-543X

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✦ Synopsis


Immunoelectrophoretic analysis of adsorbed heterologous antiserum indicated

that rhabdomyosarcomas induced by nickel sulfide gained four to five "tumorspecific" antigens and lost one to two "muscle-specific" antigens. Serum from tumor-bearing and immunized rats contained tumor-specific antibodies, as shown by the indirect fluorescent antibody technique to stain cultured tumor cells. Antigen appeared to be located in the cytoplasm. Cells from different tumors did not cross-react significantly but cells from a transplantable tumor did cross-react with each other through successive generations.


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