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Antigenic modulation - a major mechanism of antibody action

✍ Scribed by Lucienne Chatenoud; Jean-François Bach

Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 696 KB
Volume: 5
Category: Article
ISSN: 0167-5699
DOI: 10.1016/0167-5699(84)90061-6

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## Abstract Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). Monoclonal antibodies (mAbs) against EGFR are currently used for therapy of recurrent or metastatic disease; however, their mode of action is not complete