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Antigenic and genetic variability of human respiratory syncytial viruses (group A) isolated in Uruguay and Argentina: 1993–2001

✍ Scribed by Sandra Frabasile; Adriana Delfraro; Luján Facal; Cristina Videla; Mónica Galiano; María José de Sierra; Dora Ruchansky; Nathalia Vitureira; Mabel Berois; Guadalupe Carballal; José Russi; Juan Arbiza

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 179 KB
Volume: 71
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.10484

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✦ Synopsis

Abstract

The antigenic and genetic diversity of G glycoprotein from 25 human respiratory viruses (group A) isolated during nine consecutive epidemics (1993–2001) in Montevideo, Uruguay, and 7 strains isolated in Buenos Aires, Argentina, in the same period were analyzed. Genetic variability was evaluated by partial sequence of the G protein gene. Phylogenetic analysis indicated that most Uruguayan and Argentinean group A isolates clustered into three genotypes: GA5, GA2, and GA1. Some strains clustered into the GA3 genotype characterized previously. The antigenic analysis was carried out with a panel of anti‐G monoclonal antibodies that recognized conserved and strain‐specific epitopes. A close correlation between the antigenic and genetic relatedness of the strains analyzed was observed. J. Med. Virol. 71:305–312, 2003. © 2003 Wiley‐Liss, Inc.

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