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Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1.

✍ Scribed by Thome, Margot (author);Charton, Jean Enno (author);Pelzer, Christiane (author);Hailfinger, Stephan (author)


Book ID
115474518
Publisher
Cold Spring Harbor Laboratory
Year
2010
Tongue
English
Weight
876 KB
Volume
2
Category
Article
ISSN
1943-0264

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Cross-linking of the B cell antigen receptor (BCR) with an anti-IgM antibody has been shown to induce dramatic apoptosis in type I Burkitt's lymphoma (BL) cells. However, the apoptotic mechanism triggered via BCR remains unknown. Here we reports a mechanism of BCR ligation-induced apoptosis involvin