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Antigen processing and recognition

✍ Scribed by Steven A Porcelli; Günter Hämmerling

Book ID
104014459
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
74 KB
Volume
18
Category
Article
ISSN
0952-7915

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✦ Synopsis

Steven A Porcelli studies antigen presentation by MHC-class-I-like CD1 proteins, which mediate T cell recognition of foreign and self lipid antigens. A major current topic of interest is the regulation of innate and adaptive immunity by CD1ddependent natural killer T cells. In addition, Steven Porcelli is working on a variety of aspects of antigen processing and presentation by cells infected with Mycobacterium tuberculosis, with an emphasis on the development of new and more effective vaccines for prevention and control of disease caused by this organism.

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To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the a