✦ LIBER ✦

Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus

✍ Scribed by Gillian Z. Hastings; Michael J. Francis; D. J. Rowlands; Benjamin M. Chain

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 621 KB
Volume: 23
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830230623

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✦ Synopsis

Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor-binding ability. In this study minor receptor-binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen-presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor-group HRV; Pre-treatment of HRV l A , a minor-group virus, with HRV 1A-specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non-binding major serotype, gave no inhibition. The cell binding ability of minor-group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major-group viruses in mice.

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