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Antigen mimicry by an anti-idiotypic antibody single chain variable fragment

✍ Scribed by P.K Tripathi; H Qin; S Deng; C Xu; M Bhattacharya-Chatterjee; K.A Foon; S.K Chatterjee

Book ID: 117325985
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 449 KB
Volume: 35
Category: Article
ISSN: 0161-5890
DOI: 10.1016/s0161-5890(98)00072-8

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## Abstract Anti‐idiotype antibodies (Ab2) that immunologically mimic tumor antigens are auspicious agents for the active immunization of cancer patients. We have developed W12, a rat monoclonal IgG~1~ Ab2 to MN ‐14, a murine anti‐carcinoembryonic antigen (CEA) monoclonal antibody. W12 is specific