Antigen-independent T cell activation mediated by a very late activation antigen-like extracellular matrix receptor

✍ Scribed by Kazuhisa Takahashi; Tetsuya Nakamura; Hiroyasu Adachi; Hideo Yagita; Ko Okumura

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 350 KB
• Volume: 21
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830210634

✦ Synopsis

Antigen-independent T cell activation mediated by a very late activation antigen-like extracellular matrix receptor*

Cell-cell and cell-extracellular matrix (ECM) binding mediated by integrin molecules has been implicated in lymphocyte migration and adhesion. We describe here that ECM binding triggers antigen-independent activation of Tcell functions. Fibronectin and vitronectin, when coated on plates, not only acted synergistically on anti-CD3-induced serine esterase release in a murine cytotoxic T lymphocyte clone and interleukin 2 production in a murine helper T cell hybridoma but also could trigger these responses alone. All these stimulatory effects of ECM were abrogated by a monoclonal antibody which reacts with a unique very late activation antigen-like integrin and this monoclonal antibody, when coated on plates, exhibited a similar synergistic effect to that of ECM proteins. Therefore, ECM receptors expressed on activated Tcells appear to play an important role in triggering T cell effector functions in localized tissues abundant in ECM proteins.