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Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo

✍ Scribed by Holden, Sylvia A.; Teicher, Beverly A.; Robinson, Michael F.; Northey, David; Rosowsky, Andre


Book ID
120293461
Publisher
Springer
Year
1995
Tongue
English
Weight
822 KB
Volume
36
Category
Article
ISSN
0344-5704

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Topoisomerase inhibitor camptothecin sen
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Topoisomerases are nuclear enzymes that maintain and modulate DNA structure. Inhibitors of topoisomerases like camptothecin (CPT), etoposide, and others are widely used antitumor drugs that interfere with transcription, induce DNA strand breaks, and trigger apoptosis preferentially in dividing cells