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Antifibrotic potential of a selective COX-2 inhibitor (celecoxib) on liver fibrosis in rats

✍ Scribed by Mona M. Ftahy, Noha S. Abdl Latif, Essam F. Alalkamy…

Book ID
120915358
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
366 KB
Volume
22
Category
Article
ISSN
1618-5641

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Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase