Antiepiligrin (laminin 5) cicatricial pemphigoid complicated and exacerbated by herpes simplex virus type 2 infection

✍ Scribed by Tanya K Gilmour; Paul AR Meyer; Ed Rytina; Pamela M Todd

• Book ID: 104469086
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 245 KB
• Volume: 42
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.2001.00518.x

✦ Synopsis

SUMMARY

A 50‐year‐old man with antiepiligrin (laminin 5) cicatricial pemphigoid (AeCP) involving the eyes, mouth and skin required a combination of systemic drug therapies to suppress the ocular disease. Herpes simplex virus type 2 infection of the mouth and pharynx precipitated an acute deterioration, with laryngeal involvement and an increase in oral ulceration. This is an unusual complication of long‐term immunosuppression and illustrates some of the difficulties in the management of patients with AeCP. Clinical improvement was obtained with oral antiviral therapy and adjustment of his immunosuppressive regimen.