Antidiabetic effects of duodenojejunal bypass in an experimental model of diabetes induced by a high-fat diet

Effects of obesity induced by high-fat d

Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats

✍ Nobuyuki Sugioka; Kenta Haraya; Keizo Fukushima; Yukako Ito; Kanji Takada 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 1 views

## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61±0.0