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Antidepressants inhibit P2X4receptor function: a possible involvement in neuropathic pain relief

✍ Scribed by Kenichiro Nagata, Toshiyasu Imai, Tomohiro Yamashita, Makoto Tsuda…


Book ID
120694642
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
823 KB
Volume
5
Category
Article
ISSN
1744-8069

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We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a