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Antidepressants differentially modify the extinction of an aversive memory task in female rats

✍ Scribed by Thieza G. Melo; Geison S. Izídio; Luane S. Ferreira; Diego S. Sousa; Priscila T. Macedo; Alícia Cabral; Alessandra M. Ribeiro; Regina H. Silva

Book ID
116842337
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
440 KB
Volume
37
Category
Article
ISSN
0278-5846

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The in vivo distribution of an antidepressant drug (DMI) in male and female rats
✍ Anat Biegon; David Samuel 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 483 KB

The accumulation of IP injected 3H-desipramine (DMI) in the brain and in the liver has been studied in both male and female rats. The total amount of DMI in the brains of females is 2 to 4 times that found in the brains of males. In females the amount of DMI is highest on the day of estrus and lowes