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Antidepressant drugs affect dopamine uptake

✍ Scribed by Angelos E. Halaris; Krystyna T. Belendiuk; Daniel X. Freedman

Book ID
115772774
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
536 KB
Volume
24
Category
Article
ISSN
0006-2952

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Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression
✍ A. Randrup; C. BrΓ¦strup πŸ“‚ Article πŸ“… 1977 πŸ› Springer 🌐 English βš– 615 KB

The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. Five newer drugs--butriptyline, maprotiline, trimipramine, iprindole, and mianserine--exhibited rather potent inhibition o