Antidepressant and antipsychotic agents

✍ Scribed by Robert A. Lahti

• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 611 KB
• Volume: 66
• Category: Article
• ISSN: 0028-1042
• DOI: 10.1007/bf00368070

✦ Synopsis

Numerous studies have been reviewed concerning the relationship of the catecholamines and indoleamines to depression and its treatment with antidepressant drugs. The profusion of data on the subject suggests ~H2 the amines may be implicated in the disease, however ~H2 no convincing hypothesis is available which unites ~H2 the two. A similar situation seems to exist concerning H3c/N'CH3 the antipsychotic agents, dopamine and schizophrenia. The evidence appears to be overwhelming relating dopamine in the action of these agents and yet serious inconsistencies have been reported suggesting the need for a revision of the hypothesis regarding the mode of action of antipsychotic agents. This review covers the pharmacological, biochemical, and clinical aspects of antidepressant and antipsychotic agents. The article is intended to relate a brief historical account, test methods, standard and new agents, and theories regarding mode of action.